Nudity and sex can be turned off, and its effective. The only exception would be some very revealing clothing in some clubs, if that is stressful to you. Combat and looting are like… a VERY significant part of the game but as mentioned by another reply its not all FPS combat. Much of the fighting in my most recent playthrough was quickhacking and swords. There’s quite a bit of conversation in the game, with many quest objectives in the short-term being “meet with this person and talk at this club.” The dialogue options for the most part don’t change the end result, and any skill-checks that check your stats will provide you with a small amount of extra info or banter rather than changing the course of the whole story. I never played with many mods, except for one time when a gun I was really fond of decided to vanish. I hacked it back into the game with a mod and that was helpful, so you may want to keep a mod like that in your back pocket in case of glitches like that. I had an incredible time overall, with this being the first truly open-world game with RPG elements that I actually enjoyed. Cried at the ending I got on both of my playthroughs, was a really fun experience through and through.