I love the variety and strategy trinkets are bringing to the game in 2.4! They do add to early game inventory pressure, which for me is the most frustrating part of the game (juggling a full inventory, throwing stuff down pits, running back and forth).
If trinkets were stored in the velvet pouch instead of the main inventory it would at least keep inventory pressure the same as it is now, without adding to it.
That would be ideal but I think Evan is worried about changing the UI and increasing clutter. My suggestion to move trinkets to the velvet pouch is just about as minimal a change as you can possibly make. It gets the extra item out of the main inventory at the cost of a very minor code change.