Yes, but also no. We use giant prime numbers for cryptography because the more factors it has, the weaker the encryption becomes (because now there’s more than one answer for A * ? = B)

This actually is the main application for 2-almost primes. For example, instead of having an arbitrarily large prime be used for the hash, you could use a very large 2-almost prime as a key with its factors being used as 2 layers of hashing. I know there’s better uses, but the more I try to learn about cryptography the more confused I get

Presumably if they’re the product of exactly two factors then those factors would have to be prime, otherwise it wouldn’t be exactly two.