even when your pc is on, the drives should power off when they haven’t been utilized for a while. i used to keep my machines running 24/7, and i mean not even letting them sleep, and i have never had a drive fail. since electricity prices started going up i let them autosuspend to save money. if you have mechanical hard drives, make sure they are mounted in a proper orientation. with SSDs, there are lots of manufacturers out there, so choose a reputable one.