In the past 5 years, there have been several clinical trials investigating the potential anti-aging effects of metformin in humans. One notable study is the Targeting Aging with Metformin (TAME) trial, which aims to test whether metformin can delay or prevent age-related diseases such as cardiovascular disease, cancer, and cognitive decline. The trial has completed its planning phase and is currently recruiting participants. Other studies have also investigated the potential benefits of metformin for specific age-related conditions, such as cognitive impairment and frailty. While more research is needed to establish the safety and efficacy of metformin as an anti-aging therapy, these studies suggest that it holds promise as a potential tool to promote healthy aging.