Especially due to the effects of the opiate epidemic. I would think better painkillers that are not opiate, would help prevent people from getting hooked onto opiates via prescription due to having like a surgery. I have looked into why people become addicted to opiates about zero percent, but I've heard some anecdotes.
As far as I can tell, we've made minimal progress with inventing new painkillers. We got NSAIDs, steroids, opiates, anti-seizure medication for neuropathic pain, antidepressants for neuropathic pain, weed, capsaicin. Probably a few things I've missed. Like once a year I check to see if there's any new progress with painkillers, and it's usually nothing new. Why?
In particular I think we need a new class of painkillers.
"*My goal in creating this podcast is to discuss the science behind why we age and to share the newest research on what we can do to slow, stop and even reverse aging. In doing so, I hope to help explain the science in an easy-to-understand manner and I hope to help all our listeners in their journey to be healthier at any stage of life."*
Dr. David Sinclair is a professor of genetics and co-director of Harvard Medical School's Paul F. Glenn Center for Biology of Aging Research.
I learnt about this finding out of Finland from a study with thousands of participants over 20 years a few weeks ago. I share it here as I think it can help us improve our longevity.
Basically I set up this community to collect research and info about the [Health Benefits of Saunas](https://exploding-heads.com/c/sauna). If you are interested, I would probably start from the bottom (oldest links to newest links)
When you think how quickly the cost of supplements add up over the years - it might make the investment in an in home sauna worthwhile.
Hope you find this interesting.
D-serine, which acts on a type of N-methyl-D-aspartate receptors (NMDARs) is thought to be important for neuronal plasticity. As people age they produce less D-serine, and it is hypothesized that this is one of the reasons why it becomes more difficult to learn as we age. D-serine can be absorbed in the digestive tract and it can cross the blood-brain barrier. It is hypothesized that the D-serine levels of the aged brain can be restored via oral supplementation, reversing the cognitive decline to a degree.
The experiment used to test age-related learning deficit is the following: a rat is trained to press one of two levers to receive food. Then, the experiments switch the correct lever, such that now the rat needs to press the other lever to get the reward. The cognitive flexibility is tested by measuring how long it changes for the rat to begin pressing the other lever. Young rats learn to press the other lever quickly, while older rats continue pressing the old lever for longer. When supplemented with D-serine, the ability of the old rats to re-learn which lever to press improves dramatically. They show that D-serine supplementation has no effect on the young rats' performance, and they show that this effect is dose dependent, supporting their original hypothesis that D-serine supplementation can restore some of the brain's plasticity that is lost as the rat ages.
cross-posted from: https://exploding-heads.com/post/6383
> I started 2 new communities this week:
> - [Sauna - Health Benefits](https://exploding-heads.com/c/sauna)
> - [Ofuro Japanese Soaking Tubs](https://exploding-heads.com/c/soakingtub)
> - [Chromotherapy](https://exploding-heads.com/c/chromotherapy)
> because I learnt of research conducted over a 20 year period that suggests using a Sauna 4-7 times a week for 20 minutes at 174°F was able to reduce:
> - All Cause Mortality by 40%
> - Dementia and Alzheimers by 60%
> - Stroke Risk by 40%
> - Risk of developing Hypertension by 46%
> - Helps with Depression and Anxiety
> - Muscle Atrophy by 40%, and
> - Helps your body get rid of Heavy Metals
> This research was conducted mostly at a university in Finland with a couple of thousand people over 20 years plus they eliminated compounding factors like exercise etc. So they were comparing like with like when they measured these risk reductions.
> It appears that this is caused by heating your core body temperature and a similar effect could probably be attained using an Ofuro Japanese Soaking Tub. I am told these tubs are part of their daily routine in Japan, there is a switch in the kitchen they click while preparing dinner - the tub automatically fills and heats so it is ready for you after dinner and before you go to bed. I was told it was a secret to Japanese longevity along with their diet.
> Upon learning this, I:
> - was annoyed we had not been told about this before
> - wanted to learn how and why it worked - was it BS or not
> - could I get a Sauna in my house and if so, how much would it cost
> - would an Ofuro Japanese Soaking Tub do the same job? If so, could I get one in my house, how much etc?
> - which of those 2 options would be easier to use.
> I noticed Chromotherapy was also included in many Saunas sold today and I wondered why. While there is not as much hard evidence, there is research that shows some interesting benefits. So I also started a community for Chromotherapy
> So if you know about Saunas, Chromotherapy and Ofuros I would sure appreciate you contributing to the communities. If you don't, I am going to share useful links as I find them.
> I am not in the business of selling or installing Saunas, Chromotherapy or Ofuros - just generally curious if they can improve our health and are practical for the average person to use.
> Imagine the impact this could have on our medical expenses and our enjoyment of life. I hope you find this interesting.
> I suggest you start with this video https://exploding-heads.com/post/6391